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List of target antigens in pemphigus
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    List of target antigens in pemphigus

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    Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

    Target antigens for the different pemphigus variants
    Pemphigus variant Antibody isotype Antigen Molecular weight (KDa)
    Mucosal pemphigus vulgaris IgG Desmoglein 3 130
    Mucocutaneous pemphigus vulgaris IgG Desmoglein 3
    Desmoglein 1
    130
    160
    Pemphigus foliaceus IgG Desmoglein 1 160
    Paraneoplastic pemphigus IgG Desmoglein 3
    Desmoglein 1
    BPAG1
    Plectin
    Desmoplakin I
    Desmoplakin II
    Envoplakin
    Periplakin
    Alpha-2-macroglobulin-like-1
    130
    160
    230
    500
    250
    210
    210
    190
    170
    Drug-induced pemphigus IgG Desmoglein 3
    Desmoglein 1
    130
    160
    Subcorneal pustular dermatosis type of IgA pemphigus IgA1 Desmocollin 1 110/100
    Intraepidermal neutrophilic type of IgA pemphigus IgA1 Unknown
    Pemphigus erythematosus (Senear–Usher syndrome) IgG Desmoglein 1 160
    Fogo selvagem IgG Desmoglein 1 160
    Pemphigus vegetans IgG Desmoglein 3 130
    Pemphigus vegetans of Hallopeau IgG Desmoglein 3 130
    Pemphigus vegetans of Neumann IgG Desmoglein 3 130
    Pemphigus herpetiformis IgG Desmoglein 3
    Desmoglein 1
    130
    160

    See also

    • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
    • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

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