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Lithium citrate

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Lithium citrate
Lithiumcitrat V2.svg
Names
Other names
Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.011.860
EC Number
  • 213-045-8
PubChem CID
RTECS number
  • TZ8616000
UNII
  • InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 checkY
    Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K checkY
  • InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    Key: WJSIUCDMWSDDCE-DFZHHIFOAV
  • [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
Properties
Li3C6H5O7
Molar mass 209.923 g mol−1
Appearance Odorless white powder
Melting point decomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302, H319
P305+P351+P338
Flash point N/A
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Lithium citrate (Li3C6H5O7) is a chemical compound of lithium and citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder. There is extensive pharmacology of lithium, the active component of this salt.

Lithia water contains various lithium salts, including the citrate.

History

An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water. The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948 after it was banned by the Food and Drug Administration.

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder. It can be administered orally in the form of a syrup.



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