Lotilaner

Lotilaner

Clinical data
Trade names	Credelio, Credelio Cat
License data	US DailyMed: Lotilaner
Routes of administration	By mouth
ATCvet code	QP53BE04 (WHO)
Legal status
Legal status	US: ℞-only EU: Rx-only
Identifiers
IUPAC name 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number	1369852-71-0
PubChem CID	76959255
ChemSpider	32699771
UNII	HEH4938D7K
KEGG	D11212
ChEMBL	ChEMBL3707310
Chemical and physical data
Formula	C20H14Cl3F6N3O3S
Molar mass	596.75 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cc1cc(C2=NO[C@@](c3cc(Cl)c(Cl)c(Cl)c3)(C(F)(F)F)C2)sc1C(=O)NCC(=O)NCC(F)(F)F
InChI InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1 Key:HDKWFBCPLKNOCK-SFHVURJKSA-N

Lotilaner, sold under the brand name Credelio, is a veterinary medication used to control fleas and ticks in dogs and cats. It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).

Lotilaner in combination with milbemycin oxime is sold under the brand name Credelio Plus. It is used in dogs to treat concurrent infestations with parasites living outside (ticks and/or fleas) and inside (worms) the animal's body.

External links

• "Lotilaner". Drug Information Portal. U.S. National Library of Medicine.