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Loviride
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    Loviride

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    Loviride
    Loviride.svg
    Clinical data
    Other names R089439; loveride
    ATC code
    • None
    Identifiers
    • 2-[(2-Acetyl-5-methylphenyl)amino]-2-(2,6-dichlorophenyl)acetamide
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    ChEMBL
    Chemical and physical data
    Formula C17H16Cl2N2O2
    Molar mass 351.23 g·mol−1
    3D model (JSmol)
    • Clc1cccc(Cl)c1C(Nc2cc(ccc2C(=O)C)C)C(=O)N
    • InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23) checkY
    • Key:CJPLEFFCVDQQFZ-UHFFFAOYSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Loviride is an experimental antiviral drug manufactured by Janssen (now part of Janssen-Cilag) that is active against HIV. Loviride is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that entered phase III clinical trials in the late 1990s, but failed to gain marketing approval because of poor potency. It is of clinical significance only in those patients who were enrolled in clinical trials to evaluate loviride (e.g., CAESAR and AVANTI), because in those trials loviride was often given alone and with no companion drug, leading to a high probability of developing reverse transcriptase mutations such as K103N which result in cross-class resistance to the NNRTIs efavirenz and nevirapine.


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