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Eli Lilly and Company
LY-379,268
Другие языки:

    LY-379,268

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    LY-379,268
    LY3792682DACS.svg
    Identifiers
    • (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEBI
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C7H9NO5
    Molar mass 187.151 g·mol−1
    3D model (JSmol)
    • C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N
    • InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 ☒N
    • Key:YASVRZWVUGJELU-MDASVERJSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).

    It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals, and blocks the effects of PCP and DOI, which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia in animals.

    There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.

    See also


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