MB-3 (drug)

MB-3 (drug)

Identifiers
IUPAC name (2R,3S)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid
PubChem CID	21579153
Chemical and physical data
Formula	C9H12O4
Molar mass	184.191 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O
InChI InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1 Key:SRQUTZJZABSZRQ-RQJHMYQMSA-N

MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5, which usually functions as a negative modulator of PGC-1α, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.

See also

• HY-124798