Meclofenoxate

Meclofenoxate

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N06BX01 (WHO)
Legal status
Legal status	US: Not FDA approved In general: ℞ (Prescription only)
Identifiers
IUPAC name 2-Dimethylaminoethyl (4-chlorophenoxy)acetate
CAS Number	51-68-3 Y
PubChem CID	4039
ChemSpider	3899 N
UNII	C76QQ2I0RG
KEGG	D00993 Y
CompTox Dashboard (EPA)	DTXSID9046940
ECHA InfoCard	100.000.107
Chemical and physical data
Formula	C12H16ClNO3
Molar mass	257.71 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1)OCC(=O)OCCN(C)C
InChI InChI=1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3 N Key:XZTYGFHCIAKPGJ-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests. Meclofenoxate also increases cellular membrane phospholipids. It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.

Side effects

Meclofenoxate is considered to be safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.

Research

Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.

Brand names

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl. In the US, meclofenoxate is sold as a dietary supplement, although it is an unapproved drug.

See also

• Adafenoxate
• Cyprodenate
• ISRIB