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Experimental cancer drugs
Merestinib
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    Merestinib

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    Merestinib
    INN: Merestinib
    Merestinib.png
    Clinical data
    Routes of
    administration    		 PO
    ATC code
    • none
    Identifiers
    • N-(3-Fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
    CAS Number
    ChemSpider
    UNII
    KEGG
    Chemical and physical data
    Formula C30H22F2N6O3
    Molar mass 552.542 g·mol−1
    3D model (JSmol)
    • Cc1ccc(c(=O)n1c2ccc(cc2)F)C(=O)Nc3ccc(c(c3)F)Oc4cc5cnn(c5cc4c6c[nH]nc6)C
    • InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/h3-16H,1-2H3,(H,33,34)(H,36,39)
    • Key:QHADVLVFMKEIIP-UHFFFAOYSA-N

    Merestinib (LY2801653) is an experimental cancer drug in development by Eli Lilly. It is a small molecule inhibitor of MET and several other receptor tyrosine kinases such as MST1R, FLT3, AXL, MERTK, TEK, ROS1, NTRK1/2/3, and DDR1/2.

    Meristinib is part of a phase II clinical trial for advanced billiary tract cancer. The study is expected to be complete in April 2018. Phase II clinical trials for non-small cell lung cancer and solid tumors began in November 2016.


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