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Fungicides
Metyltetraprole
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    Metyltetraprole

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    Metyltetraprole
    Metyltetraprole.png
    Names
    IUPAC name
    1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methylphenyl]-4-methyltetrazol-5-one
    Identifiers
    3D model (JSmol)
    ChEBI
    ChemSpider
    PubChem CID
    UNII
    • InChI=1S/C19H17ClN6O2/c1-13-4-3-5-17(26-19(27)24(2)22-23-26)16(13)12-28-18-10-11-25(21-18)15-8-6-14(20)7-9-15/h3-11H,12H2,1-2H3
      Key: XUQQRGKFXLAPNV-UHFFFAOYSA-N
    • CC1=C(C(=CC=C1)N2C(=O)N(N=N2)C)COC3=NN(C=C3)C4=CC=C(C=C4)Cl
    Properties
    C19H17ClN6O2
    Molar mass 396.84 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Metyltetraprole is a quinone outside inhibitor fungicide sold under the brand name Pavecto by its inventor, Sumitomo Chemical. It is the only tetrazolinone fungicide and the only one in the Fungicide Resistance Action Committee's subgroup 11A.It is a inhibitor of the respiratory chain (Complex III), this making it non specific of fungus, it will inhibit all organisms with mitochondria.

    Development

    Metyltetraprole was developed specifically to find an a.i. with the same mode of action (a QoI) but with sufficiently different chemistry as to avoid "critical" QoI resistance increasing around the world.

    Target pathogens

    Metyltetraprole is highly effective against Alternaria triticina.

    Resistance

    Developed because of increasing resistance to the main group of QoIs. See §Development above.

    Cross-resistance

    It does not suffer cross-resistance with the resistance against 11 conferred by the cytochrome b mutation G143A. Cross-resistance against F129L is unassessed.


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