ML2-SA1

ML2-SA1

Identifiers
IUPAC name 5-(2,6-dichlorophenyl)-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
PubChem CID	137553170
Chemical and physical data
Formula	C14H13Cl2NO
Molar mass	282.16 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc4cccc(Cl)c4C3=NOC2C1CC(CC1)C23
InChI InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2 Key:NBXVMFMMTKYFQP-UHFFFAOYSA-N

ML2-SA1 (EVP-22) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML2 calcium channel, with high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2 from macrophages and stimulating macrophage migration and endolysosomal trafficking.

See also

• MK6-83
• SN-2