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Pharmacology stubs
Neostigmine/glycopyrronium bromide
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    Neostigmine/glycopyrronium bromide

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    Neostigmine/glycopyrronium bromide
    Combination of
    Neostigmine Cholinesterase inhibitor
    Glycopyrronium bromide Antimuscarinic agent
    Clinical data
    Trade names Prevduo
    Other names Neostigmine methylsulfate/glycopyrrolate, glycopyrronium bromide/neostigmine metilsulfate
    License data
    Routes of
    administration    		 Intravenous
    ATC code
    Legal status
    Legal status

    Neostigmine/glycopyrronium bromide, sold under the brand name Prevduo , is a fixed-dose combination medication used for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery. It contains neostigmine as the methylsulfate, a cholinesterase inhibitor, and glycopyrronium bromide, an antimuscarinic agent.

    Neostigmine/glycopyrronium bromide was approved for medical use in the United Kingdom in 2007, and in the United States in February 2023.

    Medical uses

    Neostigmine/glycopyrronium bromide is indicated for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery, while decreasing the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) associated with cholinesterase inhibition following non-depolarizing neuromuscular blocking agent reversal administration.



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