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Non-cirrhotic portal fibrosis
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    Non-cirrhotic portal fibrosis

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    Non-cirrhotic portal fibrosis
    Autosomal recessive - en.svg
    Non-cirrhotic portal fibrosis is inherited in an autosomal recessive manner

    Non-cirrhotic portal fibrosis (NCPF) is a chronic liver disease and type of non-cirrhotic portal hypertension (NCPH).

    Presentation

    It is characterized by 'obliterative portovenopathy', which leads to various problems such as portal hypertension, massive splenomegaly, and variceal bleeding. It is estimated that about 85% of people with NCPF have repeated episodes of variceal bleeding.

    Diagnosis

    Hallmark of the disease is thrombosis/sclerosis of branches of portal vein. Vessels formed are often termed as mesangiosinusoids or periportal cavernoma.

    Treatment

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