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NOSH-aspirin
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NOSH-aspirin

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Chemical structure of NOSH-Aspirin, with highlighted aspirin (green), sulfide-releasing (yellow), and nitric oxide-releasing (blue) groups.

NOSH-Aspirin is a category of new hybrids of aspirin, bearing both nitric oxide (NO)- and hydrogen sulfide (H2S)- releasing areas. Preliminary studies have found that four NOSH variants, evaluated in eleven different human cancer cell lines, were effective in inhibiting the growth of these cell lines. NOSH-1 was also devoid of any cellular toxicity, and was comparable to aspirin in its anti-inflammatory properties.


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