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Pharmacology stubs
NPS-2143
Другие языки:

    NPS-2143

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    NPS-2143
    NPS-2143 structure.png
    Identifiers
    • 2-chloro-6-[(2R)-3-([1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino)-2-hydroxypropoxy]benzonitrile
    CAS Number
    PubChem CID
    IUPHAR/BPS
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C24H25ClN2O2
    Molar mass 408.919 g·mol−1
    3D model (JSmol)
    • N#Cc2c(Cl)cccc2OCC(O)CNC(C)(C)Cc3ccc1ccccc1c3
    • InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
    • Key:PZUJQWHTIRWCID-HXUWFJFHSA-N

    NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.


    See also


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