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Antiinfective agent stubs
Oltipraz
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Oltipraz

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Oltipraz
Oltipraz.png
Clinical data
ATC code
  • none
Identifiers
  • 4-methyl-5-(2-pyrazinyl)-3-dithiolethione
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.058.833
Chemical and physical data
Formula C8H6N2S3
Molar mass 226.33 g·mol−1
3D model (JSmol)
  • CC1=C(SSC1=S)C2=NC=CN=C2
  • InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3 ☒N
  • Key:CKNAQFVBEHDJQV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical, which can be toxic.



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