Omidenepag

Omidenepag

Clinical data
Trade names	Eybelis, Omlonti
Other names	UR-7276, DE-117, Omidenepag isopropyl (JAN JP)
Routes of administration	Topical eye drops
ATC code	S01EX06 (WHO)
Legal status
Legal status	US: ℞-only Rx-only
Identifiers
IUPAC name Propan-2-yl 2-[[6-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]pyridin-2-yl]amino]acetate
CAS Number	1187451-41-7 1187451-19-9
PubChem CID	44230575 44230999
DrugBank	DB15071
ChemSpider	44210451 57643658
UNII	Z95F9F9LU4 G0G0H52U6K
KEGG	D10965 D10966
ChEMBL	ChEMBL3707245 ChEMBL4297666
Chemical and physical data
Formula	C26H28N6O4S
Molar mass	520.61 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)OC(=O)CNC1=CC=CC(CN(CC2=CC=C(C=C2)N2C=CC=N2)S(=O)(=O)C2=CC=CN=C2)=N1
InChI InChI=1S/C23H22N6O4S/c30-23(31)15-25-22-6-1-4-19(27-22)17-28(34(32,33)21-5-2-11-24-14-21)16-18-7-9-20(10-8-18)29-13-3-12-26-29/h1-14H,15-17H2,(H,25,27)(H,30,31) Key:YHGSTSNEOJUIRN-UHFFFAOYSA-N InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30) Key:VIQCWEGEHRBLAC-UHFFFAOYSA-N

Omidenepag, sold under the brand name Eybelis among others, is a medication used for the treatment of glaucoma and ocular hypertension.

Omidenepag was approved for medical use in Japan in 2018, and in the United States in September 2022.

Medical uses

Omidenepag is indicated for the treatment of glaucoma and ocular hypertension.

Adverse effects

The most common adverse effects of omidenepag are conjunctival hyperemia and macular edema, including cystoid macular edema.

Pharmacology

Omidenepag isopropyl is a prodrug that is converted by hydrolysis of its isopropyl ester to the active metabolite omidenepag. Omidenepag is a selective prostaglandin E2 receptor agonist.

History

Omidenepag was developed by Ube Industries and Santen Pharmaceutical.

External links

• "Omidenepag". Drug Information Portal. U.S. National Library of Medicine.
• "Omidenepag isopropyl". Drug Information Portal. U.S. National Library of Medicine.
• "Omidenepag". NCI Thesaurus.
• "Omidenepag isopropyl". NCI Thesaurus.