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Ornidazole

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Ornidazole
Ornidazole.svg
Clinical data
Trade names Xynor
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Metabolism Via liver
Elimination half-life 12-13 hours
Excretion Urine (63%) and Feces (22%)
Identifiers
  • 1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.037.099
Chemical and physical data
Formula C7H10ClN3O3
Molar mass 219.63 g·mol−1
3D model (JSmol)
  • [O-] [N+](=O)c1cnc(n1CC(O)CCl)C
  • InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3 checkY
  • Key:IPWKIXLWTCNBKN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ornidazole is an antibiotic used to treat protozoan infections. A synthetic nitroimidazole, it is commercially obtained from an acid-catalyzed reaction between 2-methyl-5-nitroimidazole and epichlorohydrin. Antimicrobial spectrum is similar to that of metronidazole and is more well tolerated; however there are concerns of lower relative efficacy.

It was first introduced for treating trichomoniasis before being recognized for its broad anti-protozoan and anti-anaerobic-bacterial capacities. has also been investigated for use in Crohn's disease after bowel resection.



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