Ornidazole
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Not to be confused with ronidazole.
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| Trade names | Xynor |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration |
Oral |
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| Pharmacokinetic data | |
| Metabolism | Via liver |
| Elimination half-life | 12-13 hours |
| Excretion | Urine (63%) and Feces (22%) |
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| ECHA InfoCard | 100.037.099 |
| Chemical and physical data | |
| Formula | C7H10ClN3O3 |
| Molar mass | 219.63 g·mol−1 |
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Ornidazole is an antibiotic used to treat protozoan infections. A synthetic nitroimidazole, it is commercially obtained from an acid-catalyzed reaction between 2-methyl-5-nitroimidazole and epichlorohydrin. Antimicrobial spectrum is similar to that of metronidazole and is more well tolerated; however there are concerns of lower relative efficacy.
It was first introduced for treating trichomoniasis before being recognized for its broad anti-protozoan and anti-anaerobic-bacterial capacities. has also been investigated for use in Crohn's disease after bowel resection.
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Antifolates (inhibit bacterial purine metabolism, thereby inhibiting DNA and RNA synthesis) |
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Quinolones (inhibit bacterial topoisomerase and/or DNA gyrase, thereby inhibiting DNA replication) |
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Anaerobic DNA inhibitors |
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| Authority control: National |
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