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Paraoxon

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Paraoxon
Paraoxon structure.svg
Paraoxon-3D-balls.png
Clinical data
ATC code
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • Diethyl 4-nitrophenyl phosphate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.005.657
Chemical and physical data
Formula C10H14NO6P
Molar mass 275.197 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1ccc(OP(=O)(OCC)OCC)cc1
  • InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3 checkY
  • Key:WYMSBXTXOHUIGT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Paraoxon is a parasympathomimetic which acts as an cholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an ophthalmological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication. It is easily absorbed through skin, and was allegedly used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast.

See also


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