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Pharmacology stubs
Proroxan
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Proroxan

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Proroxan
Proroxan.svg
Clinical data
Other names Pyrroxane, Pirroksan
Legal status
Legal status
  • Rx in Russia
Identifiers
  • 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-(3-phenylpyrrolidin-1-yl)propan-1-one
CAS Number
PubChem CID
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
Formula C21H23NO3
Molar mass 337.419 g·mol−1
3D model (JSmol)
  • C1CN(CC1C2=CC=CC=C2)CCC(=O)C3=CC4=C(C=C3)OCCO4
  • InChI=1S/C21H23NO3/c23-19(17-6-7-20-21(14-17)25-13-12-24-20)9-11-22-10-8-18(15-22)16-4-2-1-3-5-16/h1-7,14,18H,8-13,15H2
  • Key:GZIISXIDAZYOLI-UHFFFAOYSA-N

Proroxan (INN; also known as pyrroxane and pirroksan) is a pharmaceutical drug used as an antihypertensive and in the treatment of Ménière’s disease, motion sickness, and allergic dermatitis.

Proroxan is a non-selective alpha-blocker (α-adrenoreceptor antagonist).

Proroxan was developed in the 1970s at the Institute of Toxicology of the USSR Ministry of Health and today is primarily used in Russia. Though originally developed as an antihypertensive, its use can lead to a decrease in alcohol and drug consumption. Currently proroxan is used almost exclusively in psychiatry, narcology, and neurology.


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