| Exotoxin A | |||||||
|---|---|---|---|---|---|---|---|
 Exotoxin A dimer, Pseudomonas aeruginosa
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| Identifiers | |||||||
| Organism | |||||||
| Symbol | eta | ||||||
| UniProt | P11439 | ||||||
| Other data | |||||||
| EC number | 2.4.2.36 | ||||||
| |||||||
The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa.Vibrio cholerae produces a similar protein called the Cholix toxin (Q5EK40).
It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin.
It has been investigated as a treatment for hepatitis B and cancer.
External links
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Media related to Pseudomonas exotoxin at Wikimedia Commons - P11439 (eta) in InterPro domain view
