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Norepinephrine–dopamine reuptake inhibitors
Pyrovalerone
Другие языки:

Pyrovalerone

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Pyrovalerone
Pyrovalerone.svg
Pyrovalerone3d.png
Clinical data
Routes of
administration		 Oral
ATC code
  • none
Legal status
Legal status
Identifiers
  • (RS)-1-(4-methylphenyl)-2-(1-pyrrolidinyl)pentan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.230.426
Chemical and physical data
Formula C16H23NO
Molar mass 245.366 g·mol−1
3D model (JSmol)
Chirality Racemic mixture
  • O=C(C(CCC)N1CCCC1)C2=CC=C(C)C=C2
  • InChI=1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3 checkY
  • Key:SWUVZKWCOBGPTH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries, and although pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. It is closely related on a structural level to a number of other stimulants, such as α-PVP, MDPV and prolintane (Promotil, Katovit).

Side effects of pyrovalerone include anorexia or loss of appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal following abuse upon discontinuation often results in depression.

The R-enantiomer of pyrovalerone is devoid of activity.

See also

Look up pyrovalerone in Wiktionary, the free dictionary.



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