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Pharmacology stubs
QX39
Другие языки:

    QX39

    Подписчиков: 0, рейтинг: 0
    QX39
    QX39 structure.png
    Identifiers
    • N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide
    CAS Number
    PubChem CID
    Chemical and physical data
    Formula C20H14ClNO
    Molar mass 319.79 g·mol−1
    3D model (JSmol)
    • C1C(=NC2=C(O1)C=C(C=C2)Cl)C3=CC=C(C=C3)C4=CC=CC=C4
    • InChI=1S/C20H14ClNO/c21-17-10-11-18-20(12-17)23-13-19(22-18)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-12H,13H2
    • Key:RJFBVAUZKPHMJI-UHFFFAOYSA-N

    QX39 (Compound A, CA39) is a synthetic compound that activates chaperone-mediated autophagy (CMA) by increasing the expression of the lysosomal receptor for this pathway, LAMP2A lysosomes. It showed potent activity in vitro but has poor pharmacokinetic properties and was not suitable for animal research. Subsequent research led to the development of CA77.1, a CMA activator suitable for in vivo use.



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