Sarolaner

Sarolaner

Clinical data
Trade names	Simparica
Other names	PF-6450567
ATCvet code	QP53BE03 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
CAS Number	1398609-39-6
PubChem CID	73169092
ChemSpider	31458198
UNII	DM113FTW7F
KEGG	D10668
ChEMBL	ChEMBL3137302
ECHA InfoCard	100.234.000
Chemical and physical data
Formula	C23H18Cl2F4N2O5S
Molar mass	581.36 g·mol−1
3D model (JSmol)	Interactive image
SMILES CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12
InChI InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1 Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N

Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. It is also used off-label to control sarcoptic mange and demodectic mange.

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.

Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.

External links

• "Sarolaner". Drug Information Portal. U.S. National Library of Medicine.