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Mu-opioid receptor agonists
SHR9352
Другие языки:

    SHR9352

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    SHR9352
    SHR9352.svg
    Identifiers
    • (1'S)-N-[2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethyl]spiro[1,3-dithiolane-2,4'-2,3-dihydro-1H-naphthalene]-1'-amine
    PubChem CID
    Chemical and physical data
    Formula C28H36N2OS2
    Molar mass 480.73 g·mol−1
    3D model (JSmol)
    • C1CCC2(C1)C[C@](CCO2)(CCN[C@H]3CCC4(C5=CC=CC=C35)SCCS4)C6=CC=CC=N6
    • InChI=1S/C28H36N2OS2/c1-2-8-23-22(7-1)24(10-13-28(23)32-19-20-33-28)29-17-14-26(25-9-3-6-16-30-25)15-18-31-27(21-26)11-4-5-12-27/h1-3,6-9,16,24,29H,4-5,10-15,17-21H2/t24-,26+/m0/s1
    • Key:WRBLHOVSELHRMG-AZGAKELHSA-N

    SHR9352 is a drug which acts as a potent and selective biased agonist at the μ-opioid receptor, selective for activation of the G-protein signalling pathway over β-arrestin 2 recruitment. It was structurally derived from oliceridine by replacing the benzylic side chain with a cyclised group, although only some compounds in the series retained the desired biased agonist profile, with some derivatives such as compound 12 being potent, unbiased μ-opioid full agonists.

    Compound 12 from Li et al. [1]

    See also

    External links

    • Media related to SHR9352 at Wikimedia Commons



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