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Solitomab
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    Solitomab

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    Solitomab
    Monoclonal antibody
    Type Bi-specific T-cell engager
    Source Mouse
    Target EpCAM
    Clinical data
    ATC code
    • none
    Identifiers
    CAS Number
    ChemSpider
    • none
    UNII

    Solitomab (INN; development code MT110) is an artificial bispecific monoclonal antibody that is being investigated as an anti-cancer drug. It is a fusion protein consisting of two single-chain variable fragments (scFvs) of different antibodies on a single peptide chain of about 55 kilodaltons. One of the scFvs binds to T cells via the CD3 receptor, and the other to EpCAM as a tumor antigen against gastrointestinal, lung, and other cancers.

    Mechanism of action

    A BiTE linking a T cell to a tumor cell.

    Like other bispecific antibodies, and unlike ordinary monoclonal antibodies, solitumab forms a link between T cells and its target tumor cell antigen. This causes T cells to exert cytotoxic activity on tumor cells by producing proteins like perforin and granzymes, independently of the presence of MHC I or co-stimulatory molecules. These proteins enter tumor cells and initiate the cell's apoptosis. This action mimics physiological processes observed during T cell attacks against tumor cells.


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