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Pfizer brands
Sorbinil
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Sorbinil

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Sorbinil
Structural formula of sorbinil
Ball-and-stick model of the sorbinil molecule
Names
Preferred IUPAC name
(4S)-6-Fluoro-2,3-dihydrospiro[[1]benzopyran-4,4′-imidazolidine]-2,5-dione
Other names
(S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione; CP 45634
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.210.173
KEGG
PubChem CID
UNII
  • InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
  • Fc3ccc2OCC[C@@]1(C(=O)NC(=O)N1)c2c3
Properties
C11H9FN2O3
Molar mass 236.202 g·mol−1
Appearance White to off-white powder

Sorbinil (INN) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy.Aldose reductase is an enzyme present in lens and brain that removes excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain and placenta and calf and rat lens. Sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorbinil.


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