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Pharmacokinetics
Table of medication secreted in kidney
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    Table of medication secreted in kidney

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    This is a table of medications that are secreted in the kidney.

    Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

    Medication Location Acid or base anion or cation Percentage excreted
    para-aminohippurate proximal tubule Acid anion
    furosemide proximal tubule Acid anion 100-75
    glucuronic acid-conjugates proximal tubule Acid
    glycine conjugates proximal tubule Acid
    indometacin proximal tubule Acid anion
    methotrexate proximal tubule Acid 100-75
    penicillin proximal tubule Acid anion 75-50
    (benzylpenicillin)
    probenecid proximal tubule Acid anion
    sulphate conjugates proximal tubule Acid
    thiazide diuretics proximal tubule Acid
    uric acid proximal tubule Acid
    amiloride proximal tubule Base cation
    dopamine proximal tubule Base
    histamine proximal tubule Base
    mepacrine proximal tubule Base
    morphine proximal tubule Base cation
    pethidine proximal tubule Base
    quaternary ammonium compounds proximal tubule Base
    quinine proximal tubule Base cation
    5-hydroxytryptamine (serotonin) proximal tubule Base
    triamterene proximal tubule Base
    gentamicin 100-75
    atenolol 100-75
    digoxin 100-75
    cimetidine cation 75-50
    tetracycline 75-50
    (oxytetracycline)
    neostigmine 75-50
    propantheline ~50
    tubocurarine ~50
    acetazolamide proximal tubule anion
    chlorothiazide proximal tubule anion
    saccharin proximal tubule anion
    salicylate proximal tubule anion
    atropine proximal tubule cation
    NMN proximal tubule cation
    paraquat proximal tubule cation
    procainamide proximal tubule cation
    tetraethylammonium proximal tubule cation
    chlorpromazine proximal tubule cation

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