Tardive dysmentia

Tardive dysmentia is a rarely used term introduced in a 1983 paper to describe "changes in affect, activation level, and interpersonal interaction", and hypothesized to be caused by long-term exposure to neuroleptic drugs in the same way as the much better-known syndrome of tardive dyskinesia. Several papers in the following years discussed the validity of the concept, and this small literature was reviewed in a 1993 publication by M. S. Myslobodsky, who drew attention to the "possibility that the syndrome of dysmentia is composed of occasional excessive emotional reactivity, enhanced responsiveness to environmental stimuli, and indifference to or reduced awareness of the patient's abnormal involuntary movements", but concluded that the pathophysiology was uncertain. Since then, the term has fallen into disuse, receiving at most only passing mentions in the literature.

Further reading

• Lavania, Sagar; Praharaj, Samir Kumar; Bains, Hariender Singh; Kumar, Sudhir; Rathore, Dinesh Malkan Singh; Mohanty, Sandhya; Nayak, Madhu (2013). "Does Tardive Dysmentia Really Exist?". The Journal of Neuropsychiatry and Clinical Neurosciences. 25 (1): 58–62. doi:10.1176/appi.neuropsych.12020024. PMID 23487194.
• Emsley, R; Niehaus, D.J.H; Oosthuizen, P.P; Koen, L; Chiliza, B; Fincham, D (2011). "Subjective awareness of tardive dyskinesia and insight in schizophrenia". European Psychiatry. 26 (5): 293–6. doi:10.1016/j.eurpsy.2009.12.006. PMID 20615668. S2CID 29412673.
• Breggin, Peter R (2017). "Neuroleptic (Antipsychotic) Drugs: An Epidemic of Tardive Dyskinesia and Related Brain Injuries Afflicting Tens of Millions". In Davies, James (ed.). The Sedated Society. pp. 123–61. doi:10.1007/978-3-319-44911-1_6. ISBN 978-3-319-44910-4.