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Enzyme inhibitor
TC-S 7001
Другие языки:

    TC-S 7001

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    TC-S 7001
    TCS-7001 structure.png
    Identifiers
    • 6-chloro-4-N-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]pyrimidine-2,4-diamine
    CAS Number
    PubChem CID
    ChemSpider
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C18H13ClF2N6O
    Molar mass 402.79 g·mol−1
    3D model (JSmol)
    • CC1=CNC2=NC=CC(=C12)OC3=C(C=C(C=C3F)NC4=CC(=NC(=N4)N)Cl)F
    • InChI=1S/C18H13ClF2N6O/c1-8-7-24-17-15(8)12(2-3-23-17)28-16-10(20)4-9(5-11(16)21)25-14-6-13(19)26-18(22)27-14/h2-7H,1H3,(H,23,24)(H3,22,25,26,27)
    • Key:NRSGWEVTVGZDFC-UHFFFAOYSA-N

    TC-S 7001 (Azaindole-1) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, with an IC50 of 0.6 nM at ROCK1 and 1.1 nM at ROCK2. It has vasodilatory effects and has been used in research for a variety of applications.

    See also


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