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TDI-11861
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    TDI-11861

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    TDI-11861
    TDI-11861 structure.png
    Identifiers
    • [(3R)-4-[2-[2-[[3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol
    CAS Number
    PubChem CID
    Chemical and physical data
    Formula C22H25ClF2N6O3
    Molar mass 494.93 g·mol−1
    3D model (JSmol)
    • C1COC[C@H](N1CCOC2=CC=CC=C2CC3=CN(N=C3C4=CC(=NC(=N4)N)Cl)C(F)F)CO
    • InChI=1S/C22H25ClF2N6O3/c23-19-10-17(27-22(26)28-19)20-15(11-31(29-20)21(24)25)9-14-3-1-2-4-18(14)34-8-6-30-5-7-33-13-16(30)12-32/h1-4,10-11,16,21,32H,5-9,12-13H2,(H2,26,27,28)/t16-/m1/s1
    • Key:XVGSKZXXLKUEIO-MRXNPFEDSA-N

    TDI-11861 is a chemical compound which acts as a potent and selective inhibitor of soluble adenylyl cyclase (sAC). In animal studies it reversibly inhibits sperm motility, producing temporary infertility without hormonal side effects. While TDI-11861 is at an early developmental stage and is unlikely to be developed for medical uses in humans itself, it represents an important proof of concept which may potentially lead to the development of future male contraceptive drugs.

    See also


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