Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.

Technetium (99mTc) exametazime

Другие языки:

Technetium (99mTc) exametazime

Подписчиков: 0, рейтинг: 0

Technetium (^99mTc) exametazime
Clinical data

Trade names	Ceretec
License data	US FDA: Ceretec
Routes of administration	Intravenous
ATC code	V09AA01 (WHO) V09HA02 (WHO) (labelled leucocytes)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name [[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](^3–)-N,N',N'',N''']oxotechnetium (^99mTc)
CAS Number	99944-78-2^N
PubChem CID	9552069
UNII	3B744AG22N
Chemical and physical data
Formula	C₁₃H₂₅N₄O₃Tc
Molar mass	383 g·mol⁻¹
3D model (JSmol)	Interactive image Interactive image
Chirality	racemic
SMILES CC1(C)CN2[Tc]3(N4C1)([N](O[H]O[N]3=C(C)[C@H]4C)=C(C)[C@H]2C)=O CC1(C)CN2[Tc]3(N4C1)([N](O[H]O[N]3=C(C)[C@@H]4C)=C(C)[C@@H]2C)=O
^NY (what is this?) (verify)

Technetium (^99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used by nuclear medicine physicians for the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime (the part without technetium) is sometimes referred to as hexamethylpropylene amine oxime or HMPAO, although correct chemical names are:

(NE)-N-[(3R)-3-[[3-[[(2R,3E)-3-hydroxyiminobutan-2-yl]amino]-2,2-dimethylpropyl]amino]butan-2-ylidene]hydroxylamine
or 3,3'-((2,2,-dimethyl-1,3-propanediyl)diimino)bis-2-butanone dioxime.

Chemistry

One of the two enantiomers of exametazime

The drug consists of exametazime as a chelating agent for the radioisotope technetium-99m. Both enantiomeric forms of exametazime are used—the drug is racemic. The third stereoisomer of this structure, the meso form, is not included.