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Photosensitizer
Temoporfin
Другие языки:

Temoporfin

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Temoporfin
Temoporfin.png
Clinical data
AHFS/Drugs.com International Drug Names
License data
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3,3',3'',3'''-(2,3-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.152.970
Chemical and physical data
Formula C44H32N4O4
Molar mass 680.764 g·mol−1
3D model (JSmol)
  • C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7)O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O
  • InChI=1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-
  • Key:LYPFDBRUNKHDGX-LWQDQPMZSA-N
  (verify)

Temoporfin (INN) is a photosensitizer (based on chlorin) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck . It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.

Good results were obtained in 21 of 35 patients treated in Germany.

It is photoactivated at 652 nm i.e. by red light.

Patients can remain photosensitive for several weeks after treatment.

Further reading



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