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TIE1
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TIE1

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TIE1
Identifiers
Aliases TIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11
External IDs OMIM: 600222 MGI: 99906 HomoloGene: 3957 GeneCards: TIE1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253357
NM_005424

NM_011587

RefSeq (protein)

NP_001240286
NP_005415

NP_035717

Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.33 – 118.35 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol TIE1
Alt. symbols TIE, JTK14
NCBI gene 7075
HGNC 11809
OMIM 600222
RefSeq NM_005424
UniProt P35590
Other data
EC number 2.7.1.112
Locus Chr. 1 p34-p33
Search for
Structures Swiss-model
Domains InterPro

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.

See also

External links


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