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Timeline of cancer treatment development
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Timeline of cancer treatment development

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This is a historical timeline of the development and progress of cancer treatments, which includes time of discovery, progress, and approval of the treatments.

Ancient Era

Cancer was traditionally treated with surgery, heat, or herbal (chemical) therapies.

  • 2600 BC  – Egyptian physician Imhotep recommended producing a localised infection to promote regression of tumours. According to the Ebers medical papyrus, this was done by placing a poultice near the tumour, followed by local incision.
  • BC  – Ancient Greeks, Romans, and Egyptians used heat to treat masses. Healers in ancient India used regional and whole-body hyperthermia as treatments.
  • 2 AD  – Ancient Greeks describe surgical treatment of cancer.

Modern Era

1800s

  • 1820s  – British Dr. James Arnott, "the father of modern cryosurgery", starts to use cryotherapy to freeze tumours in the treatment of breast and uterine cancers
  • 1880s  – American Dr. William Stewart Halsted develops radical mastectomy for breast cancer
  • 1890s  – German Dr. Westermark used localized hyperthermia to produce tumour regression in patients
  • 1891  – American Dr. William B. Coley, "the father of immunotherapy", starts to treat cancer patients by injecting them with streptococci, containing immunostimulatory CpG motifs
  • 1896  – French Dr. Victor Despeignes, "the father of radiation therapy", starts to use X-rays to treat cancer
  • 1896  – American Dr. Emil Grubbe starts to treat breast cancer patients with X-rays
  • 1896 Sir George Thomas Beatson invented hormonal treatment of breast cancer by bilateral ovary removal in women with inoperable breast cancer.

1900s

2000s

  • 2001  – UK NICE approves taxol for chemotherapy of breast, ovarian, and non-small cell lung cancers
  • 2002  – US FDA approves imatinib
  • 2002  – The State Food and Drug Administration of China approves Gendicine, gene therapy for cancer
  • 2002  – Corporate takeover of Dupont by BMS resulted in abandoning Etacstil breast cancer anti-estrogen (SERM/SERD) hormonal therapy drug that overcomes hormone-therapy resistance
  • 2003  – American Dr. Peter Littrup starts to treat early and metastatic breast cancer with cryoablation
  • 2004  – bevacizumab, the first approved drug to inhibit blood vessel formation by tumours, is licensed
  • 2005  – US FDA approves taxol for chemotherapy of breast, pancreatic, and non-small cell lung cancers
  • 2006  – US FDA approves herceptin
  • 2007  – US FDA approves sorafenib
  • 2007  – US FDA approves camptothecin-analogue topotecan for chemotherapy of cancer
  • 2010  – US FDA approves immunotherapy, sipuleucel-T dendritic cell vaccine for advanced prostate cancer
  • 2010  – China advances cryoimmunotherapy to treat breast, kidney, lung, liver, prostate and bone cancer
  • 2011  – US FDA approves monoclonal antibody, Ipilimumab for advanced melanoma
  • 2011  – Cuba develops and releases CimaVax-EGF, the first therapeutic cancer vaccine for lung cancer
  • 2012  – Cuba develops and releases monoclonal antibody, Racotumomab, the therapeutic cancer vaccine for lung cancer
  • 2015  – US FDA approves anti-CDK4/6, Palbociclib for advanced breast cancer
  • 2015  – US FDA approves imaging-guided High-intensity focused ultrasound for prostate cancer

See also

External links


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