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Prodrug
Tolvaptan phosphate
Другие языки:

Tolvaptan phosphate

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Tolvaptan phosphate
Tolvaptan phosphate.svg
Clinical data
Trade names Samtasu
Other names Tolvaptan sodium phosphate; OPC-61815
Identifiers
  • [(5R)-7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1-benzazepin-5-yl] dihydrogen phosphate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C26H26ClN2O6P
Molar mass 528.93 g·mol−1
3D model (JSmol)
  • CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)OP(=O)(O)O)C
  • InChI=InChI=1S/C26H26ClN2O6P/c1-16-6-3-4-7-20(16)25(30)28-19-10-11-21(17(2)14-19)26(31)29-13-5-8-24(35-36(32,33)34)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24H,5,8,13H2,1-2H3,(H,28,30)(H2,32,33,34)/t24-/m1/s1
  • Key:XTCFGVRVASPRTK-XMMPIXPASA-N

Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.

It was developed by Otsuka Pharmaceutical Co. and was approved for use in Japan in 2022.


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