Vilanterol

Vilanterol

Clinical data
License data	EU EMA: by INN
Pregnancy category	AU: B3
ATC code	R03AK10 (WHO) (+fluticasone) R03AL03 (WHO) (+umeclidinium)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
CAS Number	503068-34-6
PubChem CID	10184665
IUPHAR/BPS	7353
ChemSpider	8360167
UNII	028LZY775B
KEGG	D09696
ChEBI	CHEBI:75037
ChEMBL	ChEMBL1198857
CompTox Dashboard (EPA)	DTXSID80198318
ECHA InfoCard	100.217.751
Chemical and physical data
Formula	C24H33Cl2NO5
Molar mass	486.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
InChI InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1 Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

Vilanterol (INN, USAN) is an ultra-long-acting β₂ adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD).. The combination is also approved for the treatment of asthma in Canada, Europe, Japan and New Zealand.

Vilanterol is available in following combinations:

• with inhaled corticosteroid fluticasone furoate—fluticasone furoate/vilanterol (trade names Breo Ellipta (U.S., NZ), Relvar Ellipta (EU, RU, JPN))
• with muscarinic antagonist umeclidinium bromide—umeclidinium bromide/vilanterol (trade name Anoro Ellipta)
• with inhaled corticosteroid fluticasone furoate and muscarinic antagonist umeclidinium bromide—fluticasone furoate/umeclidinium bromide/vilanterol (trade name Trelegy Ellipta)

See also

• Salmeterol—a long-acting β₂ adrenoreceptor agonist (LABA) with a similar backbone.