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Abandoned drugs
Vofopitant
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    Vofopitant

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    Vofopitant
    Vofopitant.svg
    Clinical data
    Other names GR205171; GR-205171
    Routes of
    administration    		 Oral
    ATC code
    • none
    Identifiers
    • (2S,3S)-N-[(2-Methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl)methyl]-2-phenylpiperidin-3-amine
    CAS Number
    PubChem CID
    IUPHAR/BPS
    ChemSpider
    UNII
    Chemical and physical data
    Formula C21H23F3N6O
    Molar mass 432.451 g·mol−1
    3D model (JSmol)
    • COC1=C(C=C(C=C1)N2C(=NN=N2)C(F)(F)F)CN[C@H]3CCCN[C@H]3C4=CC=CC=C4
    • InChI=1S/C21H23F3N6O/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3/t17-,19-/m0/s1
    • Key:XILNRORTJVDYRH-HKUYNNGSSA-N

    Vofopitant (GR205171) is a drug which acts as an NK1 receptor antagonist. It has antiemetic effects as with other NK1 antagonists, and also shows anxiolytic actions in animals. It was studied for applications such as the treatment of social phobia and post-traumatic stress disorder, but did not prove sufficiently effective to be marketed.

    See also


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