Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Drugs acting on the gastrointestinal system and metabolism
Vonoprazan/amoxicillin/clarithromycin
Другие языки:

Vonoprazan/amoxicillin/clarithromycin

Подписчиков: 0, рейтинг: 0

Vonoprazan/amoxicillin/clarithromycin
Combination of
Vonoprazan Potassium-competitive acid blocker
Amoxicillin Beta-lactam antibiotic
Clarithromycin Macrolide antibiotic
Clinical data
Trade names Vonosap, Voquezna Triple Pak
License data
ATC code
Legal status
Legal status
Identifiers
KEGG

Vonoprazan/amoxicillin/clarithromycin, sold under the brand name Vonosap among others, is a co-packaged medication used for the treatment of Helicobacter pylori (H. pylori) infection. It contains vonoprazan (as the fumarate), a potassium-competitive acid blocker; amoxicillin, a beta-lactam antibiotic; and clarithromycin, a macrolide antibiotic.

It was approved for medical use in Japan in 2016, and in the United States in May 2022. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.

Further reading

  • Kajihara Y, Shimoyama T, Mizuki I (February 2017). "Analysis of the cost-effectiveness of using vonoprazan-amoxicillin-clarithromycin triple therapy for first-line Helicobacter pylori eradication". Scand J Gastroenterol. 52 (2): 238–241. doi:10.1080/00365521.2016.1250157. PMID 27806639. S2CID 25801431.
  • Nishida T, Tsujii Y, Okamoto A, Tomita R, Higaki Y, Osugi N, et al. (9 July 2019). "A Triple-Drug Blister-Packaged Drug with Vonoprazan Improves First-Line Eradication of Helicobacter pylori in Elderly Patients: A Retrospective Propensity Score-Matched Cohort Study". Digestion. 101 (5): 608–614. doi:10.1159/000501608. PMID 31288235. S2CID 195871882.
  • Okubo H, Akiyama J, Kobayakawa M, Kawazoe M, Mishima S, Takasaki Y, et al. (November 2020). "Vonoprazan-based triple therapy is effective for Helicobacter pylori eradication irrespective of clarithromycin susceptibility". J Gastroenterol. 55 (11): 1054–1061. doi:10.1007/s00535-020-01723-6. PMID 32930864. S2CID 221674785.

External links

  • "Vonoprazan". Drug Information Portal. U.S. National Library of Medicine.
  • "Amoxicillin". Drug Information Portal. U.S. National Library of Medicine.
  • "Clarithromycin". Drug Information Portal. U.S. National Library of Medicine.



Новое сообщение