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Receptor modulators
VU-0238429
Другие языки:

    VU-0238429

    Подписчиков: 0, рейтинг: 0
    VU-0238429
    VU0238429 structure.png
    Identifiers
    • 1-(4-methoxybenzyl)-5-(trifluoromethoxy)indole-2,3-dione
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C17H12F3NO4
    Molar mass 351.281 g·mol−1
    3D model (JSmol)
    • c2cc(OC)ccc2CN(C(=O)C1=O)c3ccc(cc13)OC(F)(F)F

    • COc1ccc(cc1)CN2c3ccc(cc3C(=O)C2=O)OC(F)(F)F
    • InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 checkY
    • Key:CKLGZXFOLMHCMC-UHFFFAOYSA-N checkY
      (verify)

    VU-0238429 is a drug which acts as a selective positive allosteric modulator for the muscarinic acetylcholine receptor M5. It was the first selective ligand developed for the M5 subtype, and is structurally derived from older M1-selective positive allosteric modulators such as VU-0119498. Replacing the O-methyl- by a phenyl group further improves the receptor subtype selectivity.


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