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Huntington's disease
XJB-5-131
Другие языки:

    XJB-5-131

    Подписчиков: 0, рейтинг: 0
    XJB-5-131
    line drawing of XJB-5-131
    Legal status
    Legal status
    • experimental
    Identifiers
    PubChem CID
    ChemSpider
    ChEBI
    Chemical and physical data
    Formula C53H80N7O9
    Molar mass 959.26 g·mol−1
    3D model (JSmol)
    • CC(C)CC(C=CC(Cc1ccccc1)C(=O)N2CCCC2C(=O)NC(C(C)C)C(=O)NC(CCCNC(=O)OCc3ccccc3)C(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)NC(=O)OC(C)(C)C
    • InChI=1S/C53H80N7O9/c1-35(2)30-40(56-50(66)69-51(5,6)7)27-26-39(31-37-20-14-12-15-21-37)48(64)59-29-19-25-43(59)46(62)58-44(36(3)4)47(63)57-42(24-18-28-54-49(65)68-34-38-22-16-13-17-23-38)45(61)55-41-32-52(8,9)60(67)53(10,11)33-41/h12-17,20-23,26-27,35-36,39-44H,18-19,24-25,28-34H2,1-11H3,(H,54,65)(H,55,61)(H,56,66)(H,57,63)(H,58,62)/b27-26+/t39-,40-,42+,43+,44+/m1/s1
    • Key:VDQKIDYOPUMJGQ-VQPCLXHQSA-N

    XJB-5-131 is a synthetic antioxidant. In a mouse model of Huntington's disease, it has been shown to reduce oxidative damage to mitochondrial DNA, and to maintain mitochondrial DNA copy number. XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death.


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