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Zofenopril

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Zofenopril
Zofenopril structure.svg
Clinical data
Trade names Zocardis (RU)
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code
Identifiers
  • (2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H23NO4S2
Molar mass 429.55 g·mol−1
3D model (JSmol)
  • O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
  • InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1 ☒N
  • Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Zofenopril (INN) is a medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.

In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.

Zofenopril is a prodrug with zofenoprilat as the active metabolite.

It was patented in 1978 and approved for medical use in 2000.


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