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Pharmacology stubs
(S,S)-Tetrahydrochrysene
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    (S,S)-Tetrahydrochrysene

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    (S,S)-Tetrahydrochrysene
    (S,S)-Tetrahydrochrysene.svg
    Clinical data
    Other names (S,S)-THC
    Identifiers
    • (S,S)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
    PubChem CID
    ChemSpider
    ChEMBL
    Chemical and physical data
    Formula C22H24O2
    Molar mass 320.432 g·mol−1
    3D model (JSmol)
    • CC[C@H]1CC2=C(C=CC(=C2)O)C3=C1C4=C(C[C@@H]3CC)C=C(C=C4)O
    • InChI=1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m0/s1
    • Key:MASYAWHPJCQLSW-KBPBESRZSA-N

    (S,S)-Tetrahydrochrysene ((S,S)-THC) is a steroid-like nonsteroidal estrogen and agonist of both the estrogen receptors, ERα and ERβ. It is an enantiomer of (R,R)-tetrahydrochrysene ((R,R)-THC), which, in contrast, is an ERβ silent antagonist and ERα agonist with 10-fold selectivity (i.e., affinity) for the ERβ over the ERα and with 20-fold greater affinity for the ERβ relative to that of (S,S)-THC.

    See also



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