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4-Fluorophenibut
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Clinical data | |
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Other names | CGP-11130; β-(4-Fluorophenyl)-γ-aminobutyric acid; β-(4-Fluorophenyl)-GABA; Baflofen; Fluorophenibut; F-Phenibut; Fluoribut |
Routes of administration |
By mouth |
Identifiers | |
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PubChem CID | |
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Chemical and physical data | |
Formula | C10H12FNO2 |
Molar mass | 197.209 g·mol−1 |
3D model (JSmol) | |
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4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABAB receptor agonist which was never marketed. It is selective for the GABAB receptor over the GABAA receptor (IC50 = 1.70 μM and > 100 μM, respectively). The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA). It is less potent as a GABAB receptor agonist than baclofen but more potent than phenibut.
The substance is sometimes referred to as 4F-phenibut or F-phenibut and colloquially as fluorobut.
Legal status
F-Phenibut is a prohibited substance in Lithuania and Hungary.