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World Anti-Doping Agency prohibited substances
7β-Hydroxy-DHEA
Другие языки:

    7β-Hydroxy-DHEA

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    7β-Hydroxy-DHEA
    7β-Hydroxy-DHEA.svg
    Names
    IUPAC name
    3β,7β-Dihydroxyandrost-5-en-17-one
    Systematic IUPAC name
    (3aS,3bR,4R,7S,9aR,9bS,11aS)-4,7-Dihydroxy-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-one
    Other names
    7β-OH-DHEA; Androst-5-en-3β,7β-diol-17-one
    Identifiers
    3D model (JSmol)
    ChEBI
    ChEMBL
    ChemSpider
    PubChem CID
    UNII
    • InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-15,17,20-21H,3-9H2,1-2H3/t12-,13-,14-,15-,17-,18-,19-/m0/s1
      Key: OLPSAOWBSPXZEA-GCNMQWDSSA-N
    • C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)[C@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O
    Properties
    C19H28O3
    Molar mass 304.430 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    7β-Hydroxydehydroepiandrosterone (7β-hydroxy-DHEA; 7β-OH-DHEA), also known as 3β,7β-dihydroxyandrost-5-ene-17-one, is an endogenous, naturally occurring steroid and a metabolite of dehydroepiandrosterone (DHEA). The major metabolic pathway of DHEA outside the liver is via 7-hydroxylation into 7α-OH-DHEA and 7β-OH-DHEA. 7β-OH-DHEA has weak antiestrogenic activity, selectively antagonizing the estrogen receptor ERβ.

    7β-OH-DHEA is on the World Anti-Doping Agency list of prohibited substances in sporting.

    See also



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