Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide

Combination of
Adapalene	Retinoid
Benzoyl peroxide	Peroxide
Clinical data
Trade names	Epiduo, Epiduo Forte
Routes of administration	Topical
ATC code	D10AD53 (WHO) D10AE51 (WHO)
Legal status
Legal status	US: ℞-only In general: ℞ (Prescription only)
Identifiers
CAS Number	1194805-81-6 N
KEGG	D10792 N
NY (what is this?)  (verify)

Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris. It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.

It is available as a generic medication.

Medical uses

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.

Side effects

Commonly reported side effects include the following:

• Skin redness
• Scaling
• Dry skin
• Contact dermatitis
• Skin irritation
• Stinging
• Burning

Research

Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.

The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

External links

• "Adapalene mixture with benzoyl peroxide". Drug Information Portal. U.S. National Library of Medicine.