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Pfizer brands
CP-94253
Другие языки:

    CP-94253

    Подписчиков: 0, рейтинг: 0
    CP-94253
    CP-94253 Structure.svg
    Identifiers
    • 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine
    CAS Number
    PubChem CID
    IUPHAR/BPS
    ChemSpider
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C15H19N3O
    Molar mass 257.337 g·mol−1
    3D model (JSmol)
    • c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2
    • InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 ☒N
    • Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain; reducing food intake and promoting satiety; enhancing the reinforcing effects of cocaine; and possible antidepressant effects. A recent study found that "Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.


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