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Fluoroestradiol F-18
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Fluoroestradiol F-18

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Fluoroestradiol F-18
Fluoroestradiol F-18.png
Clinical data
Trade names Cerianna
Other names [18F]16α-Fluoroestradiol; [18F]16α-Fluoroestra-1,3,5(10)-triene-3,17β-diol
License data
Routes of
administration
Intravenous injection
Drug class Estrogen; Diagnostic radiopharmaceutical
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Liver
Excretion Gallbladder and kidney
Identifiers
  • (8R,9S,13S,14S,16R,17R)-16-(18F)fluoranyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C18H23[18F]O2
Molar mass 289.37
3D model (JSmol)
  • CC12CCC3C(C1CC(C2O)[18F])CCC4=C3C=CC(=C4)O
  • InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1
  • Key:KDLLNMRYZGUVMA-ZYMZXAKXSA-N

Fluoroestradiol F-18, also known as [18F]16α-fluoroestradiol and sold under the brand name Cerianna, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) imaging. It is an analog of estrogen and is used to detect estrogen receptor-positive breast cancer lesions.

Chemistry

Chemically, fluoroestradiol F-18 is [18F]16α-fluoro-3,17β-diol-estratriene-1,3,5(10).

History

Fluoroestradiol F-18 was approved for medical use in the United States in May 2020.

See also

External links


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