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Prodrug
Gidazepam
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Gidazepam

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Gidazepam
Gidazepam.svg
Gidazepam ball-and-stick model.png
Clinical data
Trade names Gidazepam IC
Routes of
administration		 Oral
Legal status
Legal status
Pharmacokinetic data
Metabolism Hepatic
Elimination half-life 86,7 hours(for active metabolite)
Excretion Renal
Identifiers
  • 2-(9-Bromo-3-oxo-6-phenyl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-2-yl)acetohydrazide
CAS Number
PubChem CID
DrugBank
  • ? ☒N
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C17H15BrN4O2
Molar mass 387.2 g·mol−1
3D model (JSmol)
  • BrC1=CC2=C(C=C1)N(CC(NN)=O)C(CN=C2C3=CC=CC=C3)=O
  • InChI=1S/C17H15BrN4O2/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)20-9-16(24)22(14)10-15(23)21-19/h1-8H,9-10,19H2,(H,21,23) checkY
  • Key:XLGCMZLSEXRBSG-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Gidazepam, also known as hydazepam or hidazepam, is a drug which is an atypical benzodiazepine derivative, developed in the Soviet Union. It is a selectively anxiolytic benzodiazepine. It also has therapeutic value in the management of certain cardiovascular disorders.

Gidazepam is a prodrug for its active metabolite 7-bromo-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (desalkylgidazepam or bromo-nordazepam). It is used as an antianxiety drug. Its anxiolytic effects can take several hours to manifest after dosing however, as it is the active metabolite which primarily gives the anxiolytic effects, and Gidazepam's half-life is among the longest of all GABA-ergic agonists.

Gidazepam active metabolite (desalkylgidazepam), responsible for its therapeutic effects

See also


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