| Hypovirus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Duplopiviricetes |
| Order: | Durnavirales |
| Family: | Hypoviridae |
| Genus: | Hypovirus |
Hypovirus is a genus of viruses, in the family Hypoviridae. Fungi serve as natural hosts. There are four species in this genus. Infection reduces the virulence of its parasitic host, making it a hyperparasite useful for blight control.
Species
The following species are recognized by the ICTV, all of which were found with Cryphonectria parasitica:
- Cryphonectria hypovirus 1
- Cryphonectria hypovirus 2
- Cryphonectria hypovirus 3
- Cryphonectria hypovirus 4
There are numerous family members affecting other plant-pathogenic fungi not yet accepted into the ICTV nomenclature. A proposal reorganizes the family into three genera. The informal family Fusariviridae is the sister group.
Structure
The diameter is around 50–80 nm. Genomes are linear, around 9–13kb in length. The genome has 1 or 2 open reading frames, named OrfA (not always present) and OrfB.
| Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
|---|---|---|---|---|---|
| Hypovirus | No true capsid | Non-enveloped | Linear | Monopartite |
The genome contains no structural proteins. The virus accordingly does not bud out of the cell (see "life cycle" below). Both ORFs of CHV1 contain a papain-like protease to the N-terminal that is autocatalyticly cleaved. OrfA (p69, P10941) cleaves into the p29 C7 protease and a nonessential p40 protein. OrfB (Q04350) cleaves into a p48 C8 protease and the RNA replicase–helicase.
Life cycle
Viral replication is cytoplasmic. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits the host cell by cell to cell movement. Fungi serve as the natural host.
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Hypovirus | Fungi | None | Cytoplasmic exchange; hyphal anastomosis | Cytoplasmic exchange; hyphal anastomosis | Cytoplasm | Cytoplasm | Cytoplasmic exchange; hyphal anastomosis |
CHV1 – Chestnut blight hypovirulence
Hypovirus CHV1 is the only hypovirus found in Europe up to 2000. It is known for reducing the virulence of the fungus that causes chestnut blight (i.e. hypovirulence).Cryphonectria parasitica, the ascomycete fungus, originated in Asia and causes the disease chestnut blight in several chestnut species (Castanea spp.). Although symptoms are mild in Asian chestnut species that have co-evolved with the fungus, they are very severe in the North American chestnut species C. dentata and also in the European sweet chestnut, C. sativa. Hypovirus has been used for protection against chestnut blight in Europe since the 1970s.
External links
- ICTV Report Hypoviridae
- Viralzone: Hypovirus
- MEROPS protease families: C7, C8