Naftidrofuryl

Naftidrofuryl

Clinical data
Trade names	Praxilene
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C04AX21 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	1 - 3.5 hours
Identifiers
IUPAC name (RS)-2-(diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydrofuran-2-ylmethyl)propanoate
CAS Number	31329-57-4 Y
PubChem CID	4417
ChemSpider	4264 Y
UNII	42H8PQ0NMJ
ChEMBL	ChEMBL1620794
CompTox Dashboard (EPA)	DTXSID3023344
ECHA InfoCard	100.045.960
Chemical and physical data
Formula	C24H33NO3
Molar mass	383.532 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(OCCN(CC)CC)C(Cc2c1ccccc1ccc2)CC3OCCC3
InChI InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 Y Key:KBAFPSLPKGSANY-UHFFFAOYSA-N Y
(verify)

Naftidrofuryl (INN), also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate, is a vasodilator used in the management of peripheral and cerebral vascular disorders. It is also claimed to enhance cellular oxidative capacity. The drug act as a selective antagonist of 5-HT₂ receptors (with action as an inverse agonist of the 5-HT_2A receptor specifically characterized). Naftidrofuryl is also licensed for the treatment of intermittent claudication due to peripheral arterial disease.

Naftidrofuryl is marketed under a variety of trade names, including Artocoron, Azunaftil, Di-Actane, Dusodril, Enelbin, Frilix, Gevatran, Iridus, Iridux, Luctor, Nafti, Naftilong, Naftodril, Nafoxal, Praxilene, Sodipryl retard, and Vascuprax.

Historically, it has been used to treat sudden idiopathic hearing loss and acute tinnitus.

Naftidrofuryl may be effective for relieving the pain of muscle cramps.

Adverse Effects

Naftidrofuryl has been associated with nausea, abdominal pain and rash. Rarely, hepatitis and liver failure have been reported.

See also

• Ketanserin
• Sarpogrelate